A new paper in the GIOTTO project framework has been published!

We are proud to share our last publication entitled “Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures”. The article has been published in the Special Issue of “Novel Materials for Biomedical Applications” of Biomolecules.

It reports the design and optimization of an injectable calcium suphate-based composite cement able to stimulate bone regeneration while inhibiting osteoclast bone resorption. To this aim, different types of strontium-containing mesoporous glass particles (Sr-MBG) were added to calcium sulphate powder to impart a pro-osteogenic effect. Anti-osteoclastogenic properties were conferred by incorporating into poly(lactic-co-glycolic)acid (PLGA) nanoparticles, a recombinant protein able to inhibit osteoclast activity (i.e., ICOS-Fc). 

Access to the full article here: https://doi.org/10.3390/biom13010094